guts n : fortitude and determination; "he didn't have the guts to try it" [syn: backbone, grit, moxie, sand, gumption]
- Dutch: ingewanden n p
- Esperanto: intestoj p, intestaro, viscero
- Finnish: sisäelimet, sisälmykset
- French: entrailles f|p, tripes f|p
- German: Eingeweide n p
- Guaraní: py'akue
- Hebrew: מעיים m|p
- Hungarian: bél
- Interlingua: tripas f|p, entranias f|p
- Italian: interiora f|p, viscere f|p
- Korean: 배알 (baeal)
- Portuguese: tripas f|p, vísceras f|p, entranhas f|p
- Romanian: maţe n p, măruntaie m|p
- Tupinambá: py'a
NOTE: translations in the sense of "courage" must be slang terms where possible - some given below are standard terms.
- present singular and imperative form of gutsen (all senses)
The digestive tract (also known as the alimentary canal) is the system of organs within multicellular animals that takes in food, digests it to extract energy and nutrients, and expels the remaining waste. The major functions of the GI tract are ingestion, digestion, absorption, and defecation.
The GI tract differs substantially from animal to animal. Some animals have multi-chambered stomachs, while some animals' stomachs contain a single chamber. In a normal human adult male, the GI tract is approximately 6.5 meters (20 feet) long and consists of the upper and lower GI tracts. The tract may also be divided into foregut, midgut, and hindgut, reflecting the embryological origin of each segment of the tract.
Upper gastrointestinal tractThe upper GI tract consists of the mouth, pharynx, esophagus, and stomach.
- The mouth contains the buccal mucosa, which contains the openings of the salivary glands; the tongue; and the tooth.
- Behind the mouth lies the pharynx, which leads to a hollow muscular tube, the esophagus.
- Peristalsis takes place, which is the contraction of muscles to propel the food down the esophagus which extends through the chest and pierces the diaphragm to reach the stomach.
Lower gastrointestinal tractThe lower GI tract comprises the intestines and anus.
Accessory organsAccessory organs to the alimentary canal include the liver, gallbladder, and pancreas. The liver secretes bile into the small intestine via the biliary system, employing the gallbladder as a reservoir. Apart from storing and concentrating bile, the gallbladder has no other specific function. The pancreas secretes an isosmotic fluid containing bicarbonate and several enzymes, including trypsin, chymotrypsin, lipase, and pancreatic amylase, as well as nucleolytic enzymes (deoxyribonuclease and ribonuclease), into the small intestine. Both of these secretory organs aid in digestion.
EmbryologyThe gut is an endoderm-derived structure. At approximately the 16th day of human development, the embryo begins to fold ventrally (with the embryo's ventral surface becoming concave) in two directions: the sides of the embryo fold in on each other and the head and tail fold towards one another. The result is that a piece of the yolk sac, an endoderm-lined structure in contact with the ventral aspect of the embryo, begins to be pinched off to become the primitive gut. The yolk sac remains connected to the gut tube via the vitelline duct. Usually this structure regresses during development; in cases where it does not, it is known as Meckel's diverticulum.
During fetal life, the primitive gut can be divided into three segments: foregut, midgut, and hindgut. Although these terms are often used in reference to segments of the primitive gut, they are nevertheless used regularly to describe components of the definitive gut as well.
Each segment of the primitive gut gives rise to specific gut and gut-related structures in the adult. Components derived from the gut proper, including the stomach and colon, develop as swellings or dilatations of the primitive gut. In contrast, gut-related derivatives—that is, those structures that derive from the primitive gut but are not part of the gut proper—in general develop as outpouchings of the primitive gut. The blood vessels supplying these structures remain constant throughout development.
Specialization of organsFour organs are subject to specialization in the kingdom Animalia.
- The first organ is the tongue which is only present in the phylum Chordata.
- The second organ is the esophagus. The crop is an enlargement of the esophagus in birds, insects and other invertebrates that is used to store food temporarily.
- The third organ is the stomach. In addition to a glandular stomach (proventriculus), birds have a muscular "stomach" called the ventriculus or "gizzard." The gizzard is used to mechanically grind up food.
- The fourth organ is the large intestine. An outpouching of the large intestine called the cecum is present in non-ruminant herbivores such as rabbits. It aids in digestion of plant material such as cellulose
PathologyThere are a number of diseases and conditions affecting the gastrointestinal system, including:
Immune functionThe gastrointestinal tract is also a prominent part of the immune system. The low pH (ranging from 1 to 4) of the stomach is fatal for many microorganisms that enter it. Similarly, mucus (containing IgA antibodies) neutralizes many of these microorganisms. Other factors in the GI tract help with immune function as well, including enzymes in the saliva and bile. Enzymes such as Cyp3A4, along with the antiporter activities, are also instrumental in the intestine's role of detoxification of antigens and xenobiotics, such as drugs, involved in first pass metabolism. Health-enhancing intestinal bacteria serve to prevent the overgrowth of potentially harmful bacteria in the gut. Microorganisms are also kept at bay by an extensive immune system comprising the gut-associated lymphoid tissue (GALT).
HistologyThe gastrointestinal tract has a uniform general histology with some differences which reflect the specialization in functional anatomy. The GI tract can be divided into 4 concentric layers:
MucosaThe mucosa is the innermost layer of the gastrointestinal tract that is surrounding the lumen, or space within the tube. This layer comes in direct contact with the food (or bolus), and is responsible for absorption and secretion, important processes in digestion.
The mucosae are highly specialized in each organ of the gastrointestinal tract, facing a low pH in the stomach, absorbing a multitude of different substances in the small intestine, and also absorbing specific quantities of water in the large intestine. Reflecting the varying needs of these organs, the structure of the mucosa can consist of invaginations of secretory glands (e.g., gastric pits), or it can be folded in order to increase surface area (examples include villi and plicae circulares).
SubmucosaThe submucosa consists of a dense irregular layer of connective tissue with large blood vessels, lymphatics and nerves branching into the mucosa and muscularis. It contains Meissner's plexus, an enteric nervous plexus, situated on the inner surface of the muscularis externa.
Muscularis externaThe muscularis externa consists of an inner circular layer and a longitudinal outer muscular layer. The circular muscle layer prevents the food from going backwards and the longitudinal layer shortens the tract. The coordinated contractions of these layers is called peristalsis and propels the bolus, or balled-up food, through the GI tract. Between the two muscle layers are the myenteric or Auerbach's plexus.
AdventitiaThe adventitia consists of several layers of epithelia. When the adventitia is facing the mesentery or peritoneal fold, the adventitia is covered by a mesothelium supported by a thin connective tissue layer, together forming a serosa, or serous membrane.
Uses of animal gut by humans
- The stomachs of calves have commonly been used as a source of rennet for making cheese.
- The use of animal gut strings by musicians can be traced back to the third dynasty of Egypt. In the recent past, strings were made out of lamb gut. With the advent of the modern era, musicians have tended to use strings made of silk, or synthetic materials such as nylon or steel. Some instrumentalists, however, still use gut strings in order to evoke the older tone quality. Although such strings were commonly referred to as "catgut" strings, cats were never used as a source for gut strings.
- Sheep gut was the original source for natural gut string used in racquets, such as for tennis. Today, synthetic strings are much more common, but the best strings are now made out of cow gut.
- Gut cord has also been used to produce strings for the snares which provide the snare drum's characteristic buzzing timbre. While the snare drum currently almost always uses metal wire rather than gut cord, the North African bendir frame drum still uses gut for this purpose.
- "Natural" sausage hulls (or casings) are made of animal gut, especially hog, beef, and lamb.
- Animal gut was used to make the cord lines in longcase clocks and for fusee movements in bracket clocks, but may be replaced by metal wire.
- The oldest known condoms, from 1640 CE, were made from animal intestine.
- National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.
guts in Afrikaans: Spysverteringstelsel
guts in Arabic: جهاز هضمي
guts in Asturian: Aparatu dixestivu
guts in Aymara: Manq'a kamana
guts in Bengali: পাচনতন্ত্র
guts in Min Nan: Siau-hoà hē-thóng
guts in Bosnian: Probavni sistem
guts in Bulgarian: Храносмилателна система
guts in Catalan: Aparell digestiu
guts in Czech: Trávicí soustava
guts in Welsh: System dreulio
guts in German: Verdauungstrakt
guts in Dhivehi: ހަޖަމުކުރާ ނިޒާމް
guts in Modern Greek (1453-): Γαστρεντερικό σύστημα
guts in Spanish: Aparato digestivo
guts in Esperanto: Digesta sistemo
guts in Persian: دستگاه گوارش
guts in French: Système digestif humain
guts in Korean: 소화 기관
guts in Croatian: Ljudska probava
guts in Indonesian: Saluran pencernaan
guts in Ido: Digestiva sistemo
guts in Icelandic: Meltingarkerfið
guts in Italian: Apparato gastrointestinale
guts in Hebrew: מערכת העיכול
guts in Latin: Apparatus digestorius
guts in Lingala: Nzelá elekaka bilía na líkundú
guts in Latvian: Gremošanas orgānu sistēma
guts in Lojban: canti
guts in Macedonian: Систем за варење
guts in Maltese: Sistema diġestiva
guts in Dutch: Maag-darmstelsel
guts in Japanese: 消化器
guts in Norwegian: Fordøyelsessystemet
guts in Polish: Układ pokarmowy człowieka
guts in Portuguese: Aparelho digestivo
guts in Quechua: Mikhuna yawri
guts in Russian: Желудочно-кишечный тракт
guts in Albanian: Sistemi i tretjes
guts in Simple English: Gastrointestinal system
guts in Slovak: Tráviaca sústava
guts in Slovenian: Prebavni trakt
guts in Serbian: Систем органа за варење
guts in Sundanese: Saluran cerna
guts in Finnish: Ruoansulatuskanava
guts in Swedish: Mag-tarmkanalen
guts in Tagalog: Sistemang panunaw
guts in Tamil: செரித்தல்
guts in Thai: ระบบย่อยอาหาร
guts in Vietnamese: Hệ tiêu hóa
guts in Turkish: Sindirim sistemi
guts in Ukrainian: Травна система
guts in Yiddish: פארדייאונג סיסטעם
guts in Chinese: 消化系统
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